454 Bio

Software Engineer

Company Description

454 Bio’s mission is to empower individuals to have greater ownership of their health with rapid, low-cost home and point-of-care sequencing technologies. We build breakthrough technology at the intersection of software, hardware, chemistry, and biology. We use this technology to champion a new era of personalized healthcare and help end the pathogen pandemics.

We are part of 4Catalyzer — a rapidly growing health-tech incubator founded by Dr. Jonathan Rothberg, an award-winning scientist and highly successful serial entrepreneur. Our 4Catalyzer sister companies include Butterfly Network, the first whole-body Ultrasound-on-Chip^TM, and Hyperfine, the first FDA-cleared portable MRI. 

We are fostering a culture of technical excellence and positive teamwork to solve real-world problems that help improve healthcare for billions of people around the world.

What We Live By

• Speed: We err on the side of doing.
• Focus: We work in 100-day sprints to meet audacious goals.
• Drive: We love and live delivering life-saving technology to the world — not a typical 9-5.
• Data-Driven: We search for the best solutions: objective, backed by data, and optimized for speed, simplicity, and scale.
• Team-Oriented: Lots of communication enables efficient collaboration and support.

What You Will Be Doing

454 is seeking a Software Engineer responsible for developing molecular biology systems to interface with novel engineering platforms.

As part of our team, your core responsibilities will be to:

• Work within multidisciplinary Engineering, Optics and Sequencing Teams to rapidly design, prototype, test, and iterate novel systems
• Plan, execute, and evaluate multiple scientific strategies in parallel where appropriate
• Develop software for novel engineering platforms
• Work with existing in-lab hardware to develop tools for signal processing and program interface
• Develop analysis tools that process sets of images for automatic ROI and color detection
• Data analysis focusing on signal extraction and signal processing
• Modeling of the phasing and statistics with regards to NGS
• Help drive towards the goal of cloud-based storage

What We Are Looking For

Baseline Skills, Experience, & Attributes:

• MS/PhD in Molecular Biology, Genomics, Computer Science, or Computational Biology
• Experience in life science tools
• Experience and knowledge of data processing for NGS highly preferred
• Deep knowledge and experience of:
  • Image processing: automatic ROI detection and analysis
  • Developing software for automated test equipment
  • Custom design and code analysis scripts
  • Python, with some knowledge of C preferred
  • Designing efficient algorithms that can run on low-end hardware
• Ability to analyze own data (fluency with R, or MATLAB preferred)
• Experience working with fluorescence is a plus
• Excellent interpersonal skills and ability to work with individuals and/or teams at all levels and disciplines

Additional Information

• Fully covered medical insurance plan, and dental & vision coverage - as a health-tech company, we place great worth on our teams’ well-being
• Competitive salaried compensation - we value our employees and show it
• Equity - we want every employee to be a stakeholder
• Pre-tax commuter benefits - we make your commute more reasonable
• Free onsite meals kitchen stocked with snacks.
• 401k plan - we facilitate your retirement goals
• Current laboratory in historic Guilford, CT

For this role, we provide visa assistance for qualified candidates.

454 does not accept agency resumes.

454 is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines.